Comment. Gastric intestinal metaplasia and smoking

How are we addressing gastric intestinal metaplasia ?

Systematic review of the prevalence of gastric intestinal metaplasia and its area-level association with smoking.

OBJECTIVES We aimed to show an area-level association between the frequency of intestinal metaplasia (IM) in Helicobacter pylori-infected patients and tobacco consumption. METHODS We systematically reviewed the literature to retrieve data on the prevalence of IM in different countries and performed an ecological analysis to quantify the association between the prevalence of IM among infected ...

Bile acid promotes intestinal metaplasia and gastric carcinogenesis.

BACKGROUND Bile acid and Helicobacter pylori (H. pylori) are important toxic factors for gastric mucosal injury. We examined the role of bile acid in promoting histologic gastritis and gastric carcinoma in Japanese patients. METHODS A total of 767 patients (452 men, mean age 51.1 years) were studied. Gastric juice was collected by gastro-endoscopic examination, and the bile acid concentration...

Pericryptal fibroblast sheath in intestinal metaplasia and gastric carcinoma.

BACKGROUND AND AIMS In the progression of chronic gastritis, gastric mucosal cells deviate from the normal pathway of gastric differentiation to an intestinal phenotype which is closely related to gastric carcinoma. However, to date, it has not been elucidated whether the intestinal metaplasia is merely a change in the epithelium or whether the underlying mesenchyme also changes from gastric ty...

Bile reflux and intestinal metaplasia in gastric mucosa.

AIM To determine associations between enterogastric bile reflux and gastric mucosal pathology. METHOD A retrospective study using fasting gastric juice bile acid measurements and antral or prestomal biopsy specimens from 350 patients, 66 of whom had previously undergone surgery that either bypassed or disrupted the pyloric sphincter. RESULTS Bile reflux was positively associated with reacti...